Dismiss Modal

Symptoms

Cancer Treatment and Bladder Inflammation (Cystitis)

Choose a preferred language

Cystitis is when the lining of your bladder becomes inflamed. It can be serious and cause bleeding in your bladder (hemorrhagic cystitis).


Symptoms of cystitis

Cystitis symptoms include:

  • Peeing often

  • The sudden need to pee

  • Pain or a burning feeling when peeing

  • Trouble starting to pee

  • Dark or bad-smelling pee

  • Blood in the pee

  • Bladder spasms, cramps, or pain and discomfort in your pelvis

  • Trouble completely emptying the bladder

  • A little pee leaking when coughing or sneezing

Tell your healthcare provider right away if you have any of these symptoms.


What causes cystitis?

Some treatments for cancer are more likely to cause cystitis. Cystitis may be caused by some chemotherapy medicines. These include:

  • Cyclophosphamide

  • Ifosfamide

  • Busulfan

  • Doxorubicin

  • Dacarbazine

  • Fludarabine

  • Cabazitaxel

You may also get cystitis if you’re having radiation treatment aimed at your pelvis. Bladder irritation can start several weeks after radiation therapy begins. It may get better a few weeks after treatment ends. Symptoms of bladder fibrosis (scarring caused by irritation) may not show up until months or even years after treatment.


How can I prevent cystitis?

If you’re at risk for cystitis, you should:

  • Pee as soon as you feel the urge and before going to bed at night.

  • Drink plenty of liquids. Most people need to drink at least 8 cups of fluid each day. Ask your healthcare provider how much fluid you should drink. Your pee should be light yellow or clear.

Your healthcare provider may shield your bladder during radiation therapy, if possible. If you are getting certain types of chemotherapy, your provider may prescribe a medicine that protects your bladder or give you extra intravenous (IV) fluids.


How is cystitis treated?

If you get cystitis, your provider may:

  • Adjust your treatment plan.

  • Give you medicine to treat pain and inflammation.

  • Provide antibiotics to treat or prevent infection.

  • Give you fluids to help flush your bladder.

  • Advise a medicine that will protect the lining of your bladder.


When to call your healthcare provider

Tell your provider right away if you have any of these:

  • Bladder or belly pain

  • Pain while peeing

  • Frequent peeing

  • Fever of 100.4°F (38°C) or higher, or as advised by your provider

  • Blood in your pee

  • Can't pee

Featured in

© 2000-2025 The StayWell Company, LLC. All rights reserved. This information is not intended as a substitute for professional medical care. Always follow your healthcare professional's instructions.

Find a doctor that's right for you.

From routine check-ups to groundbreaking treatments and beyond, Crestner Health is here to help you live your healthiest life.

Search our doctors
Related Articles
Read article
Oncology
Cancer Treatment and Kidney Damage (Nephrotoxicity)

Some cancer treatments can hurt your kidneys. If your kidneys are damaged, they are less able to remove pee and other waste from your body. And they can't work correctly. Here is what you need to know.

Read article
Oncology
Discharge Instructions After Treatment for Cancer of the Pancreas

You have been diagnosed with pancreatic cancer. This sheet will help you know how to care for yourself after treatment.

Read article
Oncology
Cancer Treatment and Your Heart Health

Heart damage is a possible side effect of certain cancer treatments. Heart problems can start during treatment. Or they may develop years after treatment is over. Here's what you need to know.

Read article
Wellness
Oncology Nurse Navigators

If you or a loved one has been diagnosed with cancer, you’re likely feeling overwhelmed or scared. The oncology nurse navigator (ONN) is a compassionate healthcare team membe who can see you through treatments and hospital visits. The ONN will guide you on your path through cancer care.